Promoter Polymorphisms of Human Paraoxonase PON1 Gene and Serum Paraoxonase Activities and Concentrations
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چکیده
منابع مشابه
Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations.
Paraoxonase (PON) is a serum enzyme with a wide species distribution. It protects lipoproteins from toxic oxidative modifications and is an antiatherogenic mechanism of major potential. Activity levels of PON are major determinants of the protective function; consequently, factors that influence PON levels are of particular relevance. The present study has identified 3 polymorphisms in the prom...
متن کاملPolymorphisms in the human paraoxonase (PON1) promoter.
Paraoxonase (PON1) is a protein component of high-density lipoprotein (HDL) particles that protects against oxidative damage to both low-density lipoprotein and HDL and detoxifies organophosphorus pesticides and nerve agents. A wide range of expression levels of PON1 among individuals has been observed. We examined the promoter region of PON1 for genetic factors that might affect PON1 activity ...
متن کاملParaoxonase-1 (PON1) promoter region polymorphisms, serum PON1 status and coronary heart disease
INTRODUCTION Serum paraoxonase-1 (PON1) retards the oxidation of low-density lipoprotein and cell membranes and is atheroprotective. Polymorphisms in the promoter region of the PON1 gene have been shown to affect serum PON1 levels and have been related to the presence of coronary heart disease (CHD) in some studies. However, contradictory results have been reported with regard to promoter regio...
متن کاملAlzheimer’s Disease and Paraoxonase 1 (PON1) Gene Polymorphisms
BACKGROUND Some studies have indicated that human paraoxonase 1 (PON1) activity shows a polymorphic distribution. The aim of this study was to determine the distribution of PON1 polymorphism in patients with Alzheimer's disease in Gorgan and compare it with a healthy control group. METHOD The study included 100 healthy individuals and 50 patients. Enzyme activity and genetic polymorphism of P...
متن کاملSerum paraoxonase 1 (PON1) measurement: an update
Paraoxonase 1 (PON1) is a widely studied enzyme based on its protective role against poisoning by organophosphate (OP) metabolites of specific OP insecticides and in vascular disease, as well as its use as biomarker of diseases involving oxidative stress, inflammation and liver diseases.This review provides an update about the current knowledge in the field of the analytical procedures that are...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2000
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.20.2.516